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Last Updated:
25 Jan 2010

 

Dr. Dongping Zhong

Education

1999, Ph.D., California Institute of Technology, Pasadena, California 

         (Advisor: Nobel Laureate, Linus Pauling Professor Ahmed H. Zewail)

Appointments

Robert Smith Associate Professor of Physics  
Associate Professor of Chemistry and Biochemistry, 2007-Present

Departments of Physics, Chemistry, and Biochemistry

Member of Biophysics, Biochemistry, and Chemical Physics Programs

The Ohio State University

Assistant Professor, 2002-2007

Departments of Physics, Chemistry, and Biochemistry (adjunct)

Member of Biophysics, Biochemistry, and Chemical Physics Programs

The Ohio State University

Postdoctoral Fellow, 1999-2002

NSF Laboratory for Molecular Sciences, California Institute of Technology

Awards and Honors

Outstanding Young Researcher Award, Overseas Chinese Physics Association, 2009
Camille Dreyfus Teacher-Scholar Award, The Camille and Henry Dreyfus Foundation, 2008-2013
Dr. Elizabeth L. Gross Award for faculty excellence, The Ohio State University, 2008
CAREER award, The National Science Foundation, 2008
Sloan Research Fellowship, The Alfred P. Sloan Foundation, 2008-2010
Robert Smith Endowed Professorship, The Ohio State University, 2007-present
Lecturer, Frontiers in Spectroscopy, The Ohio State University, 2006
Packard Fellowship, The David and Lucile Packard Foundation, 2005-2010
Guest Professorship, Huazhong University of Science and Technology, 2002-2005, 2008-2011
Milton and Francis Clauser Doctoral Prize, California Institute of Technology, 1999
The Herbert Newby McCoy Award, California Institute of Technology, 1999

Research Interests

Femtobiology (DNA repair, Circadian rhythm, Photoreceptors)

Biomolecular Recognition (Hydration dynamics, Conformation transformations)

Ultrafast Protein/Enzyme Dynamics (Heme proteins, Flavoproteins)

Publications (reverse chronological order)

2010    2009    2008   2007   2006   2005   2004   2003-1993
   
  2010
53. J. A. Stevens, J. J. Link, Y.-T. Kao, C. Zang, L. Wang and D. Zhong, J. Phys. Chem. B 114, 1498 (2010).  Ultrafast dynamics of resonance energy transfer in myoglobin: Probing local conformation fluctuations. [Web link] [PDF]
   
  2009
52. N. Ozturk, C. P. Selby, S.-H. Song, R. Ye, C. Tan, Y.-T. Kao, D. Zhong and A. Sancar, Biochemistry 48, 8585 (2009).  Comparative photochemistry of animal type 1 and type 4 cryptochromes. [Web link] [PDF]
   
51. L. Zhang, Y. Yang, Y.-T. Kao, L. Wang and D. Zhong, J. Am. Chem. Soc. 131, 10677 (2009).  Protein hydration dynamics and molecular mechanism of coupled water-protein fluctuations. [Web link] [PDF] [Supporting Information]
   
50. D. Zhong, Adv. Chem. Phys. 143, 83 (2009). (Invited review). Hydration dynamics and coupled water-protein fluctuations probed by intrinsic tryptophan. [Web link] [PDF]
   
49. C. Zang, J. A. Stevens, J. J. Link, L. Guo, L. Wang and D. Zhong, J. Am. Chem. Soc. 131, 2846 (2009).  Ultrafast proteinquake dynamics in cytochrome c. [Web link] [PDF] [Supporting Information]
   
  2008
48. Y.-T. Kao, C. Saxena, T.-F. He, L. Guo, L. Wang, A. Sancar and D. Zhong, J. Am. Chem. Soc.  130, 13132 (2008).  Ultrafast dynamics of flavins in five redox states. [Web link] [PDF]
   
47. N. Ozturk, Y.-T. Kao, C. P. Selby, I. H.  Kavakli, C. L. Partch, D. Zhong and A. Sancar, Biochemistry 47, 10255 (2008).  Purification and characterization of a type III photolyase from Caulobacter crescentus. [Web link] [PDF]
   
46. Y.-T. Kao, C. Tan, S.-H. Song, N. Ozturk, J. Li, L. Wang, A. Sancar and D. Zhong, J. Am. Chem. Soc.  130, 7695 (2008).  Ultrafast dynamics and anionic active states of the flavin cofactor in cryptochrome and photolyase. [Web link] [PDF]
   
45. W. Qiu, T. Li, L. Zhang, Y. Yang, Y.-T. Kao, L. Wang, and D. Zhong, Chem. Phys. 350, 154 (2008). (Special Issue on Femtochemistry VIII).  Ultrafast quenching of tryptophan fluorescence in proteins: Interresidue and intrahelical electron transfer. [Web link] [PDF]
   
  2007
44. N. Ozturk, S.-H. Song, S. Ozgur, C. P. Selby,  L. Morrison, C. Partch, D. Zhong, A. Sancar, in Cold Spring Harbor Symposia on Quantitative Biology, Volume LXXII: Clocks and Rhythms, B. Stillman, D. Stewart,  eds., Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY (2007) p119.  Structure and function of animal cryptochromes. [Web link] [PDF]
   
43. L. Zhang, L. Wang, Y.-T. Kao, W. Qiu, Y. Yang, O. Okobiah and D. Zhong, Proc. Natl. Acad. Sci. USA 104, 18461 (2007).  Mapping hydration dynamics around a protein surface. [Web link] [PDF] [Supporting Information]
   
42. S.-H. Song, N. Ozturk, T. R. Denaro, N. O. Arat, Y.-T. Kao, H. Zhu, D. Zhong, S. M. Reppert and A. Sancar, J. Biol. Chem.  282, 17608 (2007).  Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of Monarch butterfly. [Web link] [PDF]
   
41. Y.-T. Kao, C. Saxena, L. Wang, A. Sancar and D. Zhong, Cell Biochem. Biophys.  48, 32 (2007). (Invited review).  Femtochemistry in enzyme catalysis: DNA photolyase. [Web link] [PDF]
   
40. D. Zhong, Curr. Opin. Chem. Biol.  11, 174 (2007).  (Invited review). Ultrafast catalytic processes in enzymes. [Web link] [PDF]
   
39. W. Qiu, L. Wang, W. Lu, A. Boechler, D. A. R. Sanders and D. Zhong, Proc. Natl. Acad. Sci. USA  104, 5366 (2007).  Dissection of complex protein dynamics in human thioredoxin.  [Web link] [PDF]
   
38. T. Li, A. A. Hassanali, Y.-T. Kao, D. Zhong and S. J. Singer, J. Am. Chem. Soc.  129, 3376 (2007).
Hydration dynamics and time scales of coupled water-protein fluctuations. [Web link] [PDF] [Supporting Information]
   
  2006
37. W. Qiu, Y.-T. Kao, L. Zhang, Y. Yang, L. Wang, W. E. Stites, D. Zhong and A.H. Zewail, Proc. Natl. Acad. Sci. USA  103, 13979 (2006).  Protein surface hydration mapped by site-specific mutations. [Web link] [PDF] [Supporting Information]
   
36. L. Zhang, Y.-T. Kao, W. Qiu, L. Wang and D. Zhong, J. Phys. Chem. B  110, 18097 (2006).  Femtosecond studies of tryptophan fluorescence dynamics in proteins: Local solvation and electronic quenching. [Web link] [PDF]
   
35. J. Kim, W. Lu, W. Qiu, L. Wang, M. Caffrey and D. Zhong, J. Phys. Chem. B  110, 21994 (2006).
 Ultrafast hydration dynamics in the lipidic cubic phase: Discrete water structures in nanochannels. [Web link] [PDF]
   
34. A. Hassanali, T. Li, D. Zhong and S. Singer, J. Phys. Chem. B  110, 10497 (2006).  A molecular dynamics study of Lys-Trp-Lys: Structure and dynamics in solution following photoexcitation. [Web link] [PDF]
   
33. W. Qiu, L. Zhang, L. Wang and D. Zhong, in Femtochemistry VII:  Fundamental Ultrafast Processes in Chemistry, Physics, and Biology, A. W. Castleman, Jr., M. L. Kimble,  eds., Elsevier: Amsterdam (2006) p411.  Ultrafast hydration dynamics in protein conformational transitions. [Web link] [PDF]
   
32. C. Saxena, Y.-T. Kao, L. Wang, A. Sancar and D. Zhong, in Femtochemistry VII:  Fundamental Ultrafast Processes in Chemistry, Physics, and Biology, A. W. Castleman, Jr., M. L. Kimble,  eds., Elsevier: Amsterdam (2006) p407. Direct observation of DNA repair by photolyase. [Web link] [PDF]
   
31. D. Zhong, in Femtochemistry VII:  Fundamental Ultrafast Processes in Chemistry, Physics, and Biology, A. W. Castleman, Jr., M. L. Kimble,  eds., Elsevier: Amsterdam (2006) p346.  Ultrafast protein dynamics. [Web link] [PDF]
   
30. W. Qiu, L. Zhang, O. Okobiah, Y. Yang, L. Wang, D. Zhong and A.H. Zewail, J. Phys. Chem. B  110, 10540 (2006).  (cover story).  Ultrafast solvation dynamics of human serum albumin: Correlations with conformational transitions and site-selected recognition. [Web link] [PDF] [Supporting Information]
   
  2005
29. Y.-T. Kao, C. Saxena, L. Wang, A. Sancar and D. Zhong, Proc. Natl. Acad. Sci. USA 102, 16128 (2005).  Direct observation of thymine dimer repair in DNA by photolyase. [Web link] [PDF]
   
28. W. Qiu, L. Zhang, Y.-T. Kao, W. Lu, T. Li, J. Kim, G. Sollenberger, L. Wang and D. Zhong, J. Phys. Chem. B  109, 16901 (2005).  Ultrafast hydration dynamics in melittin folding and aggregation: Helix formation and tetramer self-assembly. [Web link] [PDF] [Supporting Information]
   
27. C. Saxena, H. Wang, I. H. Kavakli, A. Sancar and D. Zhong, J. Am. Chem. Soc.  127, 7984 (2005).  Ultrafast dynamics of resonance energy transfer in cryptochrome. [Web link] [PDF]
   
26. H. Wang,  C. Saxena,  D. Quan, A. Sancar and D. Zhong, J. Phys. Chem. B  109, 1329 (2005).  Femtosecond dynamics of flavin cofactor in DNA photolyase: Radical reduction, local solvation, and charge recombination. [Web link] [PDF]
   
  2004
25. W. Lu, W. Qiu, J. Kim, O. Okobiah, J. Hu, G. W. Gokel and D. Zhong, Chem. Phys. Letters 394, 415 (2004).  Femtosecond studies of crown ethers:  supramolecular solvation, local solvent structure and cation-π interaction. [Web link] [PDF]
   
24. C. Saxena, A. Sancar and D. Zhong, J. Phys. Chem. B 108, 18026 (2004). (cover story)
 Femtosecond dynamics of DNA photolyase:  Energy transfer of antenna initiation and electron transfer of cofactor reduction. [Web link] [PDF]
   
23. W. Lu, J. Kim, W. Qiu and D. Zhong, Chem. Phys. Letters 388, 120 (2004).
 Femtosecond studies of tryptophan solvation: correlation function and water dynamics at lipid surfaces. [Web link] [PDF]
   
  2003-1993
22. A. Douhal, D. Zhong and A.H. Zewail, in Femtochemistry and Femtobiology: Ultrafast Dynamics in Molecular Science, A. Douhal and J.Santamaria eds., World Scientific (2002) p731.
Femtosecond studies of protein-ligand hydrophobic binding and dynamics: Human serum albumin. [PDF]
   
21. D. Zhong, S.K. Pal, D. Zhang, S.I. Chan and A.H. Zewail, Proc. Natl. Acad. Sci. USA 99, 13 (2002).  Femtosecond dynamics of rubredoxin: Tryptophan solvation and resonance energy transfer in the protein. [Web link] [PDF]
   
20. X. Qu, C. Wan, H.-C. Becker, D. Zhong and A.H. Zewail, Proc. Natl. Acad. Sci. USA 98, 14212 (2001).  The anticancer drug-DNA complex: Femtosecond primary dynamics for anthracycline antibiotics function. [Web link] [PDF]  
   
19. D. Zhong, S.K. Pal, C. Wan and A.H. Zewail, Proc. Natl. Acad. Sci. USA 98, 11873 (2001).
Femtosecond dynamics of a drug-protein complex: Daunomycin with apo riboflavin-binding protein. [Web link] [PDF] 
   
18. D. Zhong and A.H. Zewail, Proc. Natl. Acad. Sci. USA 98, 11867 (2001).
Femtosecond dynamics of flavoproteins: Charge separation and recombination in riboflavin (vitamin B2)-binding protein and in glucose oxidase enzyme. [Web link] [PDF]   
   
17. D. Zhong, S.K. Pal and A.H. Zewail, CHEM PHYS CHEM 2, 219 (2001).
 Femtosecond studies of protein-DNA binding and dynamics: Histone I. [Web link] [PDF] 
   
16. D. Zhong, A. Douhal and A.H. Zewail, Proc. Natl. Acad. Sci. USA 97, 14056 (2000).
Femtosecond studies of protein-ligand hydrophobic binding and dynamics: Human serum albumin. [Web link] [PDF] 
   
15. D. Zhong, T.M. Bernhardt and A.H. Zewail, J. Phys. Chem. A 103, 10093 (1999).
Femtosecond real-time probing of reactions. 24. Time, velocity and orientation mapping of the dynamics of dative bonding in bimolecular electron transfer reactions. [Web link] [PDF]
   
14. D. Zhong and A.H. Zewail, Proc. Natl. Acad. Sci. USA 96, 2602 (1999).
Femtosecond dynamics of dative bonding: Concepts of reversible and dissociative electron transfer reactions. [Web link] [PDF]
   
13. D. Zhong, Eric W.-G. Diau, T.M. Bernhardt, S.D. Feyter, J.D. Roberts and A.H. Zewail, Chem. Phys. Letters 298, 129 (1998).  Femtosecond dynamics of valence-bond isomers of azines: Transition states and conical interactions. [Web link] [PDF] 
   
12. D. Zhong and A.H. Zewail, J. Phys. Chem. A 102, 4031 (1998).
Femtosecond real-time probing of reactions: 23. Studies of temporal, velocity, angular, and state dynamics from transition states to final products by femtosecond-resolved mass spectrometry. [Web link] [PDF]
   
11.

D. Zhong, S. Ahmad and A.H. Zewail, J. Am. Chem. Soc. 119, 5978 (1997).

Femtosecond elimination reaction dynamics  [Web link] [PDF]  
   
10.

D. Zhong, S. Ahmad, P.Y. Cheng and A.H. Zewail, J. Am. Chem. Soc. 119, 2305 (1997). 

Femtosecond nucleophilic substitution reaction dynamics. [Web link] [PDF]
   
9.

D. Zhong, P.Y. Cheng and A.H. Zewail, J. Chem. Phys. 105, 7864 (1996).

Bimolecular reactions observed by femtosecond detachment to aligned transition states: 

Inelastic and reactive dynamics. [Web link] [PDF]
   
8.

P.Y. Cheng, D. Zhong and A.H. Zewail, J. Chem. Phys. 105, 6216 (1996).

Femtosecond real-time probing of reactions. XXI. Direct observation of transition-state

dynamics and structure in charge-transfer reactions. [Web link] [PDF] 

   
7. P.Y. Cheng, D. Zhong and A.H. Zewail, J. Phys. Chem. 99, 15733 (1995).
Femtosecond, velocity-gating of complex structures in solvent cages. [Web link] [PDF]
   
6.

P.Y. Cheng, D. Zhong and A.H. Zewail, Chem. Phys. Letters 242, 369 (1995).

Microscopic salvation and femtochemistry of charge-transfer reactions: the problem of

benzene(s)-iodine binary complexes and their solvent structures. [Web link] [PDF]
   
5.

P.Y. Cheng, D. Zhong and A.H. Zewail, J. Chem. Phys. 103, 5153 (1995).

Transition state of charge-transfer reactions: Femtosecond dynamics and the concept of

harpooning in the bimolecular reaction of benzene  with iodine. [Web link] [PDF]
   
4.

P.Y. Cheng, D. Zhong and A.H. Zewail, Chem. Phys. Letters 237, 399 (1995).

Kinetic-energy, femtosecond resolved reaction dynamics.  Modes of dissociation (in

iodobenzene) from time-velocity correlations. [Web link] [PDF]
   
3.

D. Zhong, D.W. Setser, R. Sobczynski and W. Gadomski, J. Chem. Phys. 105, 5020 (1996).
Conservation of the Kr+(2P1/2) state in the reactive quenching of Kr(5s'[1/2]0) atoms by halogen-containing molecules. [Web link] [PDF]
   
2. N. Sadeghi, I. Colomb, J. Stoyanova, D.W. Setser and D. Zhong, J. Chem. Phys. 102, 2744 (1995).  Excitation transfer from Kr(5s', 3P0) and Kr(5s, 3P2) atoms to 12CO and 13CO. [Web link] [PDF]
   
1.

D. Zhong and D.W. Setser, Chem. Phys. Letters 207, 555 (1993).

Generation of Xe(6s'3P0) atoms by optical pumping in a flow reactor. Reactions with N2 and

halogen containing molecules. [Web link] [PDF]